Ropinirole Hydrochloride CAS 91374-20-8

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Model: MOS91374-20-8
Molecular formula: C16H25ClN2O
Melting point: 241-243°C
Molecular weight: 296.8355
Storage condition: Room temp

Ropinirole  hydrochloride is DopamineAgonist,it can enhance the effect of dopamine,correct the imbalance of central neurotransmitter,relieve symptoms and maintain the patient’s autonomy and activity.

Indications are mainly used for the treatment of early idiopathic Parkinson’s disease.

Pharmacological action ropinilol hydrochloride is a dopamine D2 receptor agonist, which is a selective non-ergoline dopamine D2 receptor agonist.Different from other dopamine agonists, this product has a simple chemical structure very similar to natural dopamine, which ACTS on postsynaptic receptors in striatum to compensate for the deficiency of dopamine and improve sympathetic nervous tension.Ropinilol can also be used as an adjuvant therapy for patients who already have switching on and off.It can directly act on synaptic receptors and generate continuous stimulation to them, so as to alleviate the movement fluctuation of l-dopamine, alleviate the difficulty of its movement and reduce the dosage.Dopamine receptor is divided into D1 and D2, a total of 1 subtype. When dopamine agonist binds to D1 receptor, this complex will activate adenotonin cyclase, increase the formation of cyclophosphate adenophorus, and thus promote the communication between nerve cells. However, the advantages and disadvantages of this effect still need to be further studied.In contrast, agonist binding to D2 receptor may inhibit or have no effect on adenocyclic enzyme.D2 receptors are located in the striatum and are thought to be involved in the anti-dopamine effect.

Pharmacokinetic ropinilol hydrochloride oral bioavailability was about 50%.When the oral dose was 1.0 ~ 5.0mg, the plasma Cmax was positively proportional to the dose, and the tmax was 1.5h.There is no accumulation in the body, mainly by oxidation metabolism, urine excretion.Mild to moderate renal dysfunction, do not need to adjust the dose.The clearance time is approximately 3.5h.

Indications: for the treatment of Parkinson’s disease


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