GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE CAS 37758-47-7 

form:lyophilized powder

Chemical Properties: Off-white powder

Ganglioside GM1 sodium salt is a specific and only receptor for cholera toxin which

facilitates the toxin’s transmembrane movement. Cells which lack Ganglioside GM1

can be toxin-resistant, further proving the role of this receptor in the cholera toxicity

mechanism. Experiments have shown Ganglioside GM1 and bis(monoacylglycerol)

phosphate (BMP) mixtures to spontaneously form small spherical vesicles of

homogenous size in an energy independent manner. In addition, this receptor has been

found to significantly decrease hydrogen peroxide-induced reactive oxygen species

accumulation in PC-12 (sc-2250) cells. It has been shown that the reduction in reactive

oxygen species is due to activation of protein kinase perceiving signal from this enzyme

and tyrosine kinase Trk-receptors. We supply the Ganglioside GM1 sodium salt form.