Prednisolone CAS 50-24-8  

Side effects with short term use include nausea and feeling tired. More severe side effects include

psychiatric problems, which may occur in about 5% of people.[4] Common side effects with long

term use include bone loss, weakness, yeast infections, and easy bruising. While short term use in

the later part of pregnancy is safe, use long term or early in early pregnancy is occasionally associated

with harm to the baby. It is aglucocorticoid made from hydrocortisone (cortisol).Prednisolone is a steroid

medication used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and 

cancers.Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid

arthritis, dermatitis, eye inflammation, asthma, andmultiple sclerosis. It is used by mouth, injection

into a vein, as a skin cream, and as eye drops.

Prednisolone was discovered and approved for medical use in 1955. It is on the World Health Organization’s

List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available

as a generic medication.The wholesale cost in the developing world is about 0.01 to 0.02 USD per day.

Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity,

making it useful for the treatment of a wide range of inflammatory and autoimmune conditions such as 

asthma, uveitis, pyoderma gangrenosum, rheumatoid arthritis, ulcerative colitis,pericarditis, temporal

arteritis and Crohn’s disease, Bell’s palsy, multiple sclerosis, cluster headaches, vasculitis, acute lymphoblastic

leukemia and autoimmune hepatitis, systemic lupus erythematosus, Kawasaki disease, dermatomyositis,and sarcoidosis.

Prednisolone can also be used for allergic reactions ranging from seasonal allergies to drug allergic reactions.

Prednisolone can also be used as an immunosuppressive drug for organ transplants.

Prednisolone in lower doses can be used in cases of primary adrenal insufficiency (Addison’s disease).

Corticosteroids inhibit the inflammatory response to a variety of inciting agents and, it is presumed, delay

or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary

proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation.