Tazobactam acid CAS 89786-04-9 cl298741 TAZOBACTAM

Chemical Properties: White or off-white powder

Usage:b-lactamase inhibitor

Definition: ChEBI: A member of the class of penicillanic acids that is sulbactam in which

one of the exocyclic methyl hydrogens is replaced by a 1,2,3-triazol-1-yl group; used (in the

form of its sodium salt) in combination with ceftolozane sulfate for treatment of complicat d

intra-abdominal infections and complicated urinary tract infections.

Raw materials: Etanol–>Potassium permanganate–>Sodium azide–>Potassium iodide–>

Celite –>Ammonium acetate–>Peroxyacetic acid–>Vinyl acetate–>Potassium bromide–>

3-Amino-5-mercapto-1,2,4-triazole–>Sulbactam–>phenylhydrazone–>Tazobactam sodium

Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially

those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug

 piperacillin/tazobactam, used in infections duePseudomonas aeruginosa. Tazobactam broadens

the spectrum of piperacillin by making it effective against organisms that express β-lactamase 

and would normally degrade piperacillin.

Tazobactam is a heavily modified penicillin and a sulfone.

Tazobactam was patented in 1982 and came into medical use in 1992.