Desmopressin acetate (CAS: 16789-98-3)

Function: 

central diabetes insipidus, nocturnal enuresis and hemophilia, also used for kidney urine concentration

function test. Also used for postoperative bleeding.

Dosage and administration:

Control hemorrhage or to prevent bleeding before invasive surgery: 0.3 ug/kg body weight, subcutaneous drug

or diluted with normal saline to 50-100 ml, intravenous drip in 15 to 30 minutes. If curative effect is positive, can

according to the initial dose of 6 to 12 hours repeat dosing 1-2 times, further repeat dosing may be less effective.

Hemophiliac VIII: C concentration reaches expected value according to the principle of the same as the use factor

VIII concentrate to estimate, during the medication should be conducted on a regular basis VIII: the concentration

of C tracking monitoring, because of some leap, repeated to lower after the drug efficacy against nanchang. If intravenous

drip annotated medicine didn’t make VIII in plasma; C concentration reaches the expected increase, should add with factor

VIII concentrate for treatment. For the treatment of patients with hemophilia, should refer to the coagulation test results

for each patient to determine treatment plan.

Pharmacologic action:

It is a structural analogue of natural arginine vasopressin, a derivative of vasopressin. Its antidiuretic effect is more powerful

and lasting than vasopressin, but it has no vasoconstriction effect, and the side effects of drugs are small. The clinical use of

chemical book can prolong the bleeding time caused by congenital or drug-induced platelet dysfunction, uremia, cirrhosis and

unknown causes; it can be used to control And prevention of small surgery bleeding; central diabetes insipidus and so on.