antiretroviral (RT) virus drugs, anti-hepatitis virus drugs, anti-herpes virus drugs and anti-other virus drugs.

Tenofovir is an acyclic nucleoside antiviral drug that inhibits HBV polyenzymatic polymerization and HIV

reverse transcriptase. Tenofovir’s active component, tenofovir biphosphate, inhibits viral polymerase by

directly binding to the natural deoxyribose substrate and terminates the chain by inserting DNA.It is the first

nucleotide analogue approved by the food and drug administration (FDA) for the treatment of hiv-1 infection.

Tenofovir is a drug used in HIV cocktails and studies have shown it can improve the ability of monkeys to

prevent immunodeficiency virus (HIV), which is similar to human HIV.

Pharmacokinetic tenofovir is almost not absorbed by the gastrointestinal tract, so it is esterified and salinized

to become tenofovir ester fumarate.Tenofovir esters are water-soluble and can be rapidly absorbed and degraded

into the active substance tenofovir, which is then converted into the active metabolite tenofovir bisphosphate.The

peak value of tenofovir in blood was 1 ~ 2h after administration.The bioavailability of tenofovir with food increased

by about 40%.Tenofovir bisphosphate has an intracellular half-life of about 10h and can be administered once a day.

Since the drug is not metabolized by the CYP450 enzyme family, the possibility of interaction with other drugs

caused by this enzyme is very low.