Zoledronic acid hydrate CAS 165800-06-6 

Safety Information

Azole phosphonic acid is a kind of specific effect on bone diphosphate compounds, it inhibits by osteoclasts activity increased bone resorption. Diphosphate compound effect on bone tissue selectivity depends on its high affinity of mineralized bone role of molecular mechanism is unclear. Long-term animal studies have shown that azole phosphonic acid can inhibit bone absorption, but for the formation of bone, bone mineralization and mechanical characteristics of no bad influence, in the initial 24 hours, dosage of 44 plus or minus 18% excretion in the urine, the rest of the main stranded in the bone tissue. Azole phosphonic acid and blood no affinity, and the combination of plasma protein is low (about 22%), and is not dependent on the azole phosphonic acid concentration, the injection time increased from 5 minutes to 15 minutes, at the end of the injection, azole phosphonic acid concentration was reduced by 30%, but has no effect on AUC.