Propyl 4-hydroxybenzoate (CAS: 94-13-3)

Chemical properties

Flame, high temperature combustible.

Toxicity:

Adl 0-10mg/kg(FAO/WHO,2001).

LD503.7g/kg(Mice, through the mouth).

GRAS(FDA,§184．1670,2000).

Preparation

From p-hydroxy benzoic acid and normal propyl alcohol ester.Mix p-hydroxy benzoic acid and propanol, heat to dissolve, slowly add sulfuric acid,Continue heating reflux after 8 h cooling, in 4% sodium carbonate solution crystallization precipitation, filtration, washed to neutral is the crude products,Then through ethanol recrystallization and finished products. In the preparation of, also can be used instead of sulfuric acid cation exchange resin catalyst.

Mainly by esterification method.Potassium by phenol reaction with carbon dioxide under the pressurized first made from p-hydroxy benzoic acid.Then with propyl alcohol in the presence of sulfuric acid catalyst for esterification reaction, finally after washing, bleaching, recrystallization, centrifugal dehydration and drying.

Application

1. The fungus, yeast and bacteria has broad antibacterial effect, its antibacterial effect is greater than the neper Jin Yi ester. Were used in the soy sauce, pickles in the production of food preservatives.
2. Cosmetics preservatives. Phenolic preservatives. 0.1% – 1.0%. Usually and neper Jin Ding ester mixture has good synergy, and collaborative.

Risk

Health hazard: inhalation, ingestion or absorbed through the skin harmful to the body. May stimulate the eyes and mucous membranes and upper respiratory tract and skin.

Combustion hazard: the goods combustible, stimulative.

In security terms:

S24/25:Avoid contact with skin and eyes. Avoid contact with skin and eyes.

Danger label :

R36/37/38:Stimulate eyes, respiratory system and skin. Stimulating eyes, respiratory system and skin.

Emergency treatment

Skin contact: remove contaminated clothing, with plenty of liquid water washing.

Eye contact: mention eyelid, irrigate with flowing water or normal saline. Go to a doctor.

Inhalation: from the scene to fresh air. Such as difficulty in breathing, give oxygen. Go to a doctor.

Eating: drink enough water, vomiting. Go to a doctor.

Announcements

Airtight operation, overall ventilation. Operators must receive special training, strictly abide by the operation procedures.

Storage and transportation

Store in a cool, ventilated warehouse. Away from fire and heat source. Should be stored apart and oxidant, alkali, mixed reservoir of avoid by all means. Equipped with corresponding varieties and number of fire equipment. Storage area should be equipped with the right material for leakage content.