Methyldopa CAS 555-30-6

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Model: MOS 555-30-6
Place of Origin: Sichuan,China (Mainland)
Molecular formula: C10H13NO4
Molecular weight: 211.21
Melting Point: ≥300 °C
Storage condition: Store at RT
Boiling point: 436.3°C at 760 mmHg
Refractive index: -14 ° (C=1, H2O)
Flashing point: 217.7°C
Vapour pressure: 2.19E-08mmHg at 25°C

Methyldopa (CAS: 555-30-6)

Item Index
Molecular Formula C10H13NO4
Molecular weight 211.21
Specification CP/USP/EP
Appearance White crystalline powder
Melting point ≥300 °C
Refractive index -14 ° (C=1, H2O)
 Storage   Condition Store at RT

Chemical property

White crystalline powder. Soluble in dilute hydrochloric acid, at 25 ℃ in the water solubility of about 10

mg/ml, saturated water solution pH value is about 5. Slightly soluble in ethanol, insoluble in ether and chloroform.

Production methodprocess

Vanilla aldehyde with dimethyl sulfate methyl hellebore aldehyde, again with the nitro oxide condensation

get 1 – (2 – nitro propenyl) – 3 ‘, 4 ‘- dimethoxy benzene, with iron powder reduction and generated

after hydrolysis of 3′, 4 ‘- dimethoxy

benzene acetone, Then by cyclization, open loop, hydrolysis reaction to get DL – methyldopa,

split out quick methyldopa left-handed.


Left-handed methyldopa is a B blockers core vascular medicine, to moderate program of primary and renal hypertension

has good curative effect.

Methyldopa(L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic

agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is

now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a

role in otherwise difficult to treat hypertension and gestational hypertension

(previously known as pregnancy-induced hypertension (PIH)).

It is on the World Health Organization’s List of Essential Medicines, a list of the most important

medication needed in a basic health system.

Medical uses

Methyldopa is used in the clinical treatment of the following disorders:

Hypertension (or high blood pressure)

Gestational hypertension (or pregnancy-induced hypertension) and pre-eclampsia


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