Granisetron hydrochloride (CAS: 107007-99-8)

Medical uses

Chemotherapy

It may be used for chemotherapy-induced nausea and vomiting and appears to work about the same as ondansetron.

Post operative

A number of medications including granisetron appear to be effective in controlling post-operative nausea and

vomiting (PONV). It is unclear if it is more or less effective than other agents such as droperidol, metoclopramide,

ondansetron or cyclizine.

Its efficacy has also been questioned with a research Dr. Yoshitaka Fujii having 12 published papers on this topic

in Canadian Journal of Anesthesia retracted. A further five papers in the same journal on the same drug by Dr

Fujii are considered indeterminate.

Other

Is a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis

Treatment of cyclic vomiting syndrome although there are no formal trials to confirm efficacy.