7-Ethyl-10-hydroxycamptothecin (CAS: 119577-28-5)

The material is mainly used for the preparation of hydrochloric acid, for health.

Appearance
Yellowish-white crystalline powder, 1 mg/ml dimethyl sulfoxide solution show clear yellow.

Toxicology data

Respectively: DNA damage experiment: white blood cells in mice, 2500 mu of mol/L; DNA

inhibition test: white blood cells in mice, 1 mu mol/L;

Storage transport

2-8 ℃ sealing dry and avoid light preservation.

The physical and chemical properties

This product crystallization from ethanol to pale yellow needle crystal, see light perishable,

MP228 ~ 235 ℃ (decomposition), slightly soluble in methanol, ethanol, chloroform, insoluble

in water, soluble in DMF and chloroform methanol mixture, not mixed with acid salt, react with

sodium hydroxide to open roads into sodium salt.

This product is a pale yellow crystalline powder, soluble in dimethyl sulfoxide, slightly soluble

in methanol, insoluble in ether.

Application

7 – ethyl – 10 – hydroxy camptothecin was made for preparation of antineoplastic agent hydrochloric

acid, kang (CPT – 11), the key intermediates.