Valsartan is a kind of specific angiotensin Ⅱ (AT1) receptor antagonist, is after chlorine

sand jotham and an applied to clinical the skin class AT1 receptor antagonist, in regulating

blood pressure, maintain the electrolyte fluid balance plays a key role.It selectively ACTS

on the AT1 receptor subtype, blocking Ang Ⅱ combined with AT1 receptor (its specificity

of AT1 receptor of antagonism effect about 20000 times greater than the AT2 receptors),

thus inhibiting vascular contraction and the release of aldosterone, antihypertensive effect,

but not inhibition of potassium ions (K +) caused by the release of aldosterone.Antihypertensive

effect is better than enalapril, suitable for the treatment of antihypertensive, mild to moderate

primary hypertension, especially for secondary hypertension caused by kidney damage, can

significantly reduce the hypertension patients with diabetes or normal renal function of proteinuria,

and promote the excretion of uric acid, urine sodium kidney protection.It is also used to reduce

cardiovascular mortality in high-risk patients (left ventricular failure or left ventricular dysfunction) after a heart attack.

A clinical trial has shown that valsartan has a significant effect on mild to moderate hypertension.A

single dose of 80mg or more per day can effectively control systolic and diastolic blood pressure for

24h without changing blood pressure rhythm.160mg once a day was more effective than losartan 100mg

once a day.Patients with moderate hypertension and intact renal function have good tolerance to valsartan,

and the efficacy is significantly better than that of invertase inhibitors, with slight adverse reactions.

Combination with other antihypertensive drugs is effective for severe hypertension.

This product has the following characteristics:

1. This product does not act on ACE, renin and other receptors, and does not inhibit ion channels related

to blood pressure regulation and sodium balance;This product has no inhibitory effect on angiotensin

converting enzyme and does not affect the level of bradykinin in the body, so the side effect of cough

is less than that of angiotensin converting enzyme inhibitor.

2. Lower elevated blood pressure without affecting heart rate.

3. For most patients, oral administration of a single dose has antihypertensive effect within 2 hours,

reaching the peak within 4-6 hours, and maintaining the antihypertensive effect more than 24 hours

after taking the drug.The maximum antihypertensive effect was achieved after 2-4 weeks of treatment,

and the effect was maintained during long-term treatment.Combination with thiazide diuretics can

further enhance the antihypertensive effect.

4. Sudden termination of valsartan treatment does not cause hypertension “rebound” or other side effects.