Donepezil HCL is a kind of drugs to treat alzheimer’s treatment, belong to the second generation of cholinesterase (ChE) inhibitors, clinically used for mild to moderate alzheimer’s dementia treatment, compared with other drugs has a low incidence of adverse reactions, and the characteristics of the curative effect is obvious, is the only can reach the United States food and drug administration’s drug treatment guidelines, standards, and only a kind of MCA approved by the FDA and British at the same time of new drugs to cure mild-to-moderate alzheimer’s disease.

It is believed that the pathogenesis of cognitive impairment in alzheimer’s disease is partly related to the low cholinergic neurotransmitter function.Donepezil hydrochloride may play a therapeutic role by enhancing the function of the cholinergic nerve.It can reversibly inhibit the hydrolysis of acetylcholine by acetylcholinesterase, thereby increasing the concentration of acetylcholine in the receptor site.There is no evidence that donepezil can alter the underlying course of dementia.