Chloroquine diphosphate CAS: 50-63-5

Description:

This product is white crystalline powder, odorless and bitter. The color changes with light and the aqueous solution

shows acid reaction. This product is soluble in water, almost insoluble in ethanol, chloroform and ether.

The melting point is 193-196 ℃, and it decomposes at the same time.

Specifications:

Application:

Recommended time: on February 17, 2020, sun Yanrong, deputy director of the biological center of the Ministry

of science and technology, said at a press conference held by the joint prevention and control mechanism of the

State Council that in clinical practice, the drug group of chloroquine phosphate was superior to the control group

in terms of a series of indicators, such as the rate of severity, the phenomenon of fever reduction, the time of image

improvement of the lung, the time and rate of virus nucleic acid turning negative, and the shortening of the course of disease.

Expert evaluation: novel coronavirus pneumonia was used to evaluate the efficacy of chloroquine phosphate in the treatment

of Zhong Nanshan’s New Zealand’s top pneumonia. It is considered that “the drug is an old drug that has been on the market

for many years, and the safety of the drug for the treatment of a wide range of people is controllable. Based on the novel

coronavirus pneumonia treatment, the results of the study conducted by the previous clinical institutes can be effective.

“Chloroquine phosphate is not enough for a specific drug, but it has therapeutic effect and little side effect, which is worth

studying and discussing,” Zhong Nanshan said in a question from a media reporter on February 18.

Drug profile: chloroquine phosphate has been used in the treatment of malaria since the 1940s,

and later in the treatment of rheumatoid arthritis.

How does chloroquine phosphate have antiviral effect? First, because chloroquine can change the pH value of the

endophage, it has a significant inhibitory effect on the virus infection that invades the cells through the endocytosis

pathway; second, chloroquine can affect the virus replication by inhibiting the gene expression of the virus; in addition,

as a good autophagy inhibitor, chloroquine can interfere with the virus infection and replication by influencing the autophagy reaction.

Development stage: novel coronavirus pneumonia treatment phase.

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